GPCRs associate with members of the heterotrimeric G protein family that are anchored to the intracellular surface of the plasma membrane (Bourne, 1997). These G proteins consist of an subunit (G) that binds guanine nucleotides, and a dimer that consists of a and subunit (G). The intracellular signaling events that are triggered by the activation of heterotrimeric G proteins is determined by the particular combination of G and G subunits that are present in the complex, and the availability of specific effectors and regulatory proteins.
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